A single subcutaneous injection of the mixture of a peptide drug and a polymeric
A long-acting drug delivery system is much desired in treatment of diabetes, but very challenging in pharmaceutics and material sciences. The cooperation of Ding group at Fudan University and Chen group at China State Institute of Pharmaceutical Industry results in a new delivery system using thermogelling copolymers of poly(ethylene glycol) (PEG) and biodegradable polyesters. Liraglutide, a fatty acid-modified antidiabetic polypeptide, is selected as the model drug. The drug-loaded polymer solutions are injectable at room temperature and physically gelled in situ at body temperature. The Liraglutide-loaded PCGA-PEG-PCGA thermogel formulation exhibits a sustained drug release manner for one week in both in vitro and in vivo tests. A single subcutaneous injection of this formulation shows a remarkably improved glucose tolerance of mice for one week.
The article with Mr. Yipei CHEN, a master student as the first author and Associate Professor Lin YU as the corresponding author was published in Scientific Reports 2016.
Controlled release of liraglutide using thermogelling polymers in treatment of diabetes
Yipei Chen, Yuzhuo Li, Wenjia Shen, Kun Li, Lin Yu*, Qinghua Chen, Jiandong Ding, Sci. Rep., 6: 31593 (2016)
Link: http://www.nature.com/articles/srep31593