生物医用材料课题组

CELL/BIOMATERIAL INTERACTIONS

(细胞与生物材料的相互作用)

 

 

Fabrication techniques of nanopatterns and micropatterns using block copolymer micellar nanolithography and photolithography etc. in order to control cells on molecular scale and single-cell scale

 

Graphical

图案-RGD-3.tif

 

 

Critical nanospacing of RGD peptide ligands for specific cell adhesion (focal adhesion)

 

 

  

 

 

 

 

 

 

 

Geometry control of cells, and effects of cell shape, size, contact on differentiation of  stem cells (干细胞)

 

 

 

Effects of functional groups of materials on nonspecific cell adhesion and differentiation

 

 

 

Designing deterministic experiments to reveal the effect of matrix stiffness on stem cell differentiation

 

Finding that degradation rate of materials affords a dynamic cue to regulate stem cells beyond varied matrix stiffness

 

 

 

Establishing a microfluidic system for cell studies and revealing that a dynamic stretching can lead to a perpendicular cell orientation

     

 

Controlling the surface topography of materials and achieving a significant self deformation of nuclei of cells on micropillar arrays